Figure 1.

mTOR map with transcription factors identified in this study. TFs shown in green and red are those already assigned to the mTOR pathway and re-confirmed in our study. The former are those with a regulating role in the mTOR pathway, and the latter are those regulated by the mTOR pathway genes. Gray circles are newly identified TFs with rims colored according to their regulating or regulated status in mTOR. Genes without orthologs for mice are shown in gray squares. Modules are shown upon the basic knowledge on mTOR-pathway-regulation workflow with assigned respective TFs detected in our study.