Table 4.

Diabetic nephropathy process segment interference.

Segment	# Genes in segment	Interference overlap	Biomarker candidates	Enriched pathways
1	29	7	CCL5	Chemokine signaling; Cytokine-cytokine receptor interaction; Renin-angiotensin system; Complement and coagulation cascades
18	11	2	HBA1, NFKB1, HP, HBA2	–
3	20	3	TGFB1	ECM-receptor interaction; TGF-beta signaling; PI3K-Akt signaling
4	16	2	ACTA1	–

Provided is the process segment number of the DN molecular model, number of genes assigned to the segment, number of features identified as affected according to the drug mechanism of action model, biomarkers involved in the segment (gene symbols), and relevant pathways from the DN pathway map being enriched in such segment.