Figure 2.

Nestin expression in human bone marrow biopsies. (A) Consistent expression of Nestin is detectable in the tunica intima of large vessels, arterioles and venules (dark brown color). Few cells of the sub-endothelium and adventitia show a weakly positive Nestin staining (light brownish color). Furthermore, Nestin is highly expressed in the sinusoids and two colors immunofluorescence reveals that Nestin is positive in lumen-facing cells surrounded by CD146+/Nestin− pericytes. (B) Schematic representation of possible tissue distribution of MPC (represented in green) and other bone marrow vessels-residing cells.