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A model depicts the relationship between the biological space and the prognostic space. Multiple patient subgroups exist because of tumor heterogeneity. Analogous to planets, various patients' subgroups reside on orbits, each of which carries key unique signaling pathways. Representative altered signaling pathways such as MYC, TP53, etc, are indicated. The patients' subgroups whose orbits intersect with the prognostic space are considered those with similar prognostic outcome.
