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. 2014 Aug 28;2:45. doi: 10.3389/fcell.2014.00045

Figure 1.

Figure 1

Schematic representation of PrPC. Numbering of amino acid residues corresponds to the mouse PrPC sequence. Shown are the locations of histidine (H) residues that bind copper ions (residues 60, 68, 76, 84, 95, 110), the amino (N)-terminal signal peptide (SP; residues 1–22), β-amyloid oligomer (Aβ) binding regions (residues 23–27, 95–110), the octapeptide repeat region (OR; residues 51–90), the central hydrophobic domain (HD; residues 111–130), α-helical regions (α; residues 143–152, 171–191, 199–221), β-sheet regions (β; residues 127–129, 166–168), sites of asparagine (N)-linked glycosylation (residues 180, 196), and the carboxyl (C)-terminal glycosylphosphatidylinositol (GPI) signal peptide (GSP; residues 231–254).