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. 2014 Jul 29;2:31. doi: 10.3389/fcell.2014.00031

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Copyright © 2014 Carbo, Hontecillas, Andrew, Eden, Mei, Hoops and Bassaganya-Riera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heterogeneity of CD4+ T cell subsets. T helper type 1 (Th1), type 2 (Th2), type 17 (Th17), type 9 (Th9) and type 22 (Th22), Follicular T helper cells (Tfh), and induced regulatory T cells (iTreg) as well as type 1 regulatory T cells (Tr1) are induced based on multiple cytokines being produced by dendritic cells and macrophages among other immune subsets.