Table 2.
Genetic and epigenetic alterations of miR-24, miR-125b, miR-195, and miR-214.
| miRNA gene | Chromosome locus | Disease | Genetic alteration | Epigenetic alteration | miRNA expression |
|---|---|---|---|---|---|
| miR-24-1 | 9q22.32 | ||||
| miR-24-2 | 19p13.13 | Lung cancer | Deletion | Down | |
| miR-125b-1 | 11q24.1 | AML and MDS | t(2;11)(p21;q24) | Up | |
| BCP-ALL | t(11;14)(q24;q32) | Up | |||
| Cervical cancer | Deletion | Down | |||
| Breast cancer | Epigenetic silencing | Down | |||
| miR-125b-2 | 21q21.1 | DS-AMKL | 21 trisomy | Up | |
| miR-195 | 17p13.1 | Colorectal adenoma | Deletion | Epigenetic silencing | Down |
| Colorectal cancer | Deletion | Down | |||
| Breast cancer | Epigenetic silencing | Down | |||
| Gastric cancer | Epigenetic silencing | Down | |||
| miR-214 | 1q24.3 | Liposarcoma | Gene amplification | Up | |
| Breast cancer | Deletion | Down |
AML, acute myeloid leukemia; MDS, myelodysplastic syndrome; BCP-ALL, B-cell precursor acute lymphoblastic leukemia; DS-AMKL, Down syndrome with acute megakaryocytic leukemia.