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. Author manuscript; available in PMC: 2014 Oct 23.
Published in final edited form as: Semin Cell Dev Biol. 2012 Oct 29;24(4):287–297. doi: 10.1016/j.semcdb.2012.10.006

Figure 2. Role of p85 in the WASP- and WAVE-mediated actin-cytoskeleton organization.

Figure 2

A. Stimulation of the receptor tyrosine kinase, PDGFR, leads to activation of the components of PI3K; p110 and p85. p85. By regulating the activity of Cdc42 and Rac1, PI3K regulates, in turn, the WASP- and WAVE-mediated actin polymerization. B. Schematic representation of the functional domains of WAVE3 and p85. The double-headed arrow points the interacting domains between WAVE3 (BR) and p85 (CSH2).