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. Author manuscript; available in PMC: 2014 Oct 23.
Published in final edited form as: Semin Cell Dev Biol. 2012 Oct 29;24(4):287–297. doi: 10.1016/j.semcdb.2012.10.006

Figure 3. Mechanisms of WAVE3 regulation in cancer metastasis.

Figure 3

WAVE3 is regulated by microRNA miR-200, where Epithelial-to mesenchymal transition (EMT) is critical during the early steps of cancer cell invasion. Loss of miR-31 which results in the re-activation of its metastasis promoter target genes, including WAVE3, is a defining step during the invasion-metastasis cascade. Phosphorylation of WAVE3 by c-Abl provides an additional checkpoint to modulate invadopodia formation and MMP activity.