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. Author manuscript; available in PMC: 2015 May 19.
Published in final edited form as: Curr Biol. 2014 May 19;24(10):R463–R474. doi: 10.1016/j.cub.2014.03.033

Figure 1. The proteostasis network maintains a functional proteome.

Figure 1

Molecular chaperones and the ubiquitin-proteasome system (UPS) cooperate in pathways of protein folding, refolding, disaggregation, and degradation. At the cellular level, the accumulation of protein aggregates is also managed by autophagic degradation, mitotic clearance, and physical sequestration pathways.

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