Table 2.

Estimated regression coefficients (β) and 95% CIs using orthogonal slope for β based on first- and second-phase GSIS and adipose insulin sensitivity

Insulin secretion	Insulin sensitivity	β	95% CI
Nondiabetic subjects
First-phase GSIS (0–30 min)	1/Plasma FFA × INS	−0.81	(−1.42, −0.20)
	1/Ra palmitate × INS	−0.88	(−12.81, 11.06)
Second-phase GSIS (60–120 min)	1/Plasma FFA × INS	−0.85	(−1.19, −0.50)
	1/Ra palmitate × INS	−0.87	(−1.24, −0.50)
Type 2 diabetic subjects
First-phase GSIS (0–30 min)	1/Plasma FFA × INS	−1.47	(−2.02, −0.92)
	1/Ra palmitate × INS	−0.96	(−1.27, −0.65)
Second-phase GSIS (60–120 min)	1/Plasma FFA × INS	−1.93	(−3.13, −0.73)
	1/Ra palmitate × INS	−1.21	(−2.63, 0.21)

No between-group difference in slope parameters was detected, suggesting diabetic and nondiabetic groups had similar curvilinear relationships between insulin secretion and sensitivity. INS, insulin; Ra, rate of palmitate appearance.