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. 2014 Oct 10;37(11):3054–3060. doi: 10.2337/dc14-0803

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© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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A: Time profiles of calculated EGP by glucagon dose, baseline corrected for EGP at the time of the dose. B: Mean EGP AUC over 60 min after the dose. C: Three-dimensional graph of mean EGP AUC separated by glucagon dose and insulin infusion rate. D: MATLAB-generated dose-response curve across all doses, and for low and high insulin infusion rate experiments, estimated from study data. Response means for 25-, 75-, 125-, and 175-μg doses indicated by open circles, with 95% CI error bars. Coefficients for parameters of the sigmoid curve with 95% CI: −5.8 (−50 to 272), 336.5 (−3,800 to 3,900), 759.1 (−15,800 to 15,900), and −0.8 (−30.5 to 28.9).