Fig 3.

DTI-TBSS results show that the more previous brain hemorrhage, the more white matter microstructural abnormalities (as reflected by more regions with lower FA compared with controls). Green represents the average white matter skeleton overlaid on FA images, orange/yellow represent white matter regions with significantly lower FA values (when compared with control infants, P < .05, fully corrected for multiple comparisons) in A, ELBW infants with no old blood product deposition on MR imaging at term-equivalent age, B, ELBW infants with old blood product deposition on MR imaging but no sonography IVH diagnosis after birth, C, ELBW infants with old blood product deposition on MR imaging and previous sonography diagnosis of grades 1 or 2 IVH, and D, ELBW infants with old blood product deposition on MR imaging and previous sonography diagnosis of grades 3 or 4 IVH.