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. 2014 Nov 4;3:218. Originally published 2014 Sep 11. [Version 2] doi: 10.12688/f1000research.5250.2

Table 4. Target family profiles for top five drugs with largest changes in promiscuity.

Drug name #Targets #Families Family list
Imatinib 24 7 ATP binding cassette transporters;
Carbonic anhydrases;
Multi antimicrobial extrusion (MATE) transporters;
NAD(P)H dehydrogenases (quinone);
Organic cation transporters;
Ser_Thr protein kinases;
Tyr protein kinases
Indomethacin 16 10 ATP binding cassette transporters;
Aldo/keto reductases;
Glyoxalases I;
Intercrines;
Lipoxygenases;
MAPEGs;
Organic cation transporters;
Organo anion transporters;
Potassium ion channels;
Short-chain dehydrogenases/reductases (SDR)
Risperidone 15 4 Monoamine GPCRs;
Multi antimicrobial extrusion (MATE) transporters;
Organic cation transporters;
Sodium:neurotransmitter symporters (SNF)
Furosemide 14 4 Bile acid:sodium symporters (BASS);
Carbonic anhydrases;
Carboxylic acid GPCRs;
Short-chain dehydrogenases/reductases (SDR)
Dipyridamole 12 5 ATP binding cassette transporters;
Multi antimicrobial extrusion (MATE) transporters;
Organic cation transporters;
Class C PPases;
Phosphodiesterases

For the top five drugs with largest changes in promiscuity over time, the total number of targets and families is reported. The family with the first target annotation of a drug is shown in bold. Target family abbreviation: MAPEG, membrane-associated proteins in eicosanoid and glutathione metabolism.