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Time course of mean ± SD and fitted plasma cortisol concentrations. Symbols show experimental data, and lines show the fittings to the pharmacodynamic model shown above. The baseline phase is displayed by the solid symbols and solid lines. The prednisone phase is displayed by the open symbols and broken lines. The comparative free prednisolone IC50 values of cortisol suppression are also shown for individual subjects (open circles) as well as group mean values (filled triangles).
