Table 2.
Clinical and clinical-pathologic diagnoses of the LT recipient cohorts
| Clinical diagnosis | Pathologic diagnosis | Clinical-pathologic diagnosis |
|---|---|---|
| Obliterative bronchiolitis (OB+) Group (n = 29) | ||
| Bronchiolitis obliterans syndrome | ||
| (BOS) (n = 25) | OB | Pathologic OB/BOS (n = 25) |
| Stage 0p | OB | Pathologic OB/BOS (n = 1) |
| Stage I | OB | Pathologic OB/BOS (n = 4) |
| Stage II | OB | Pathologic OB/BOS (n = 3) |
| Stage III | OB | Pathologic OB/BOS (n = 17) |
| PGD | Areas of OB with diffuse alveolar damage (DAD) | PGD (n = 3) |
| Adenovirus pneumonia | Areas of OB with hemorrhagic adenovirus pneumonia | Hemorrhagic adenovirus pneumonia (n = 1) |
| Obliterative bronchiolitis negative (OB−) Group (n = 23) | ||
| Hemothorax | Normal lung allograft | Hemothorax/normal lung allograft (n = 3) |
| Hemothorax | DAD | Hemothorax/PGD (n = 1) |
| Hemothorax/hyperammonemia | Acute rejection (AR)/lymphocytic bronchiolitis (LB) | Hemothorax/hyperammonemia/AR/LB (n = 1) |
| Hemothorax | AR/pulmonary embolism (PE) | Hemothorax/AR/PE (n = 1) |
| Hemothorax | Respiratory bronchiolitis/PE | Hemothorax/respiratory Bronchiolitis/PE (n = 1) |
| Hemothorax | Diffuse organizing pneumonia/LB | Hemothorax/atypical AR (n = 1) |
| Progressive respiratory failure/acute respiratory distress syndrome | DAD | Acute respiratory distress syndrome (n = 1) |
| Acute respiratory distress syndrome/multiorgan failure | DAD/PTLD/PE | Acute respiratory distress syndrome//multiorgan failure/PTLD/PE (n = 1) |
| Progressive respiratory failure/acute respiratory distress syndrome | DAD with capillaritis/LB | Antibody-mediated rejection (n = 1) |
| PGD | CMV pneumonitis/DAD | PGD with CMV pneumonitis (n = 2) |
| Primary graft dysfunction/ECMO | DAD | PGD (n = 1) |
| PGD/ECMO | DAD/PE | PGD/PE (n = 1) |
| Sternal wound dehiscence (SWD) | DAD | SWD with PGD (n = 1) |
| Massive unilateral PE | Angioinvasive aspergillosis/PE | Angioinvasive aspergillosis/PE (n = 1) |
| PGD | Necrotizing pneumonia/PE/infarction | Nosocomial necrotizing pneumonia/PE with infarction (n = 1) |
| Trapped lung/chylothorax | Inflamed visceral pleura/normal lung allograft | Trapped lung/chylothorax with normal lung allograft (n = 1) |
| Hyperammonemia | Normal lung allograft | Hyperammonemia/normal lung allograft (n = 1) |
| Enterococcal sepsis | Valvular vegetations with septic pulmonary embolism | Spontaneous bacterial endocarditis with septic pulmonary embolism (n = 1) |
| Sudden death | Acute PE | Acute PE (n = 1) |
| PGD/massive coagulopathy | Diffuse bilateral pulmonary hemorrhage/PE | Bilateral pulmonary hemorrhage/PE (n = 1) |
PTLD = posttransplant lymphoproliferative disease; CMV = cytomegalovirus; ECMO = extracorporeal membrane oxygenation.