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Average Pharmacodynamic Parameters for Methylprednisolone Effects on Helper T Cells Using Two Modelsa
| Model | kt(hr−1) | IC50(ng/ml) | Rm | Rb | tz(hr) |
|---|---|---|---|---|---|
| Previous [Eq. (6)] | 0.57 ± 0.20 | 7.52 ± 3.79b | 872 ± 239 | 178 ± 58 | 19.3 ± 4.4b |
| (cells/mm3) | |||||
| Present [Eq. (4)] | 0.54 ± 0.08 | 11.9 ± 4.8 | 477 ± 137 | 99 ± 27 | 17.3 ± 4.5 |
| (cells/mm3/hr) | |||||
Data are presented as mean ± standard deviation for 6 subjects. Data obtained from Fisher et al. (13).
p < 0.05 as compared by the paired t test.
