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. Author manuscript; available in PMC: 2014 Oct 23.
Published in final edited form as: J Pharmacokinet Biopharm. 1992 Aug;20(4):319–331. doi: 10.1007/BF01062461

Table II.

Average Pharmacodynamic Parameters for Methylprednisolone Effects on Helper T Cells from Three Studies in Healthy Mena

Study kt(hr−1) IC50(ng/ml) Rm(cells/mm3/hr) Rb(cells/mm3/hr) tz(hr)
Dunn et al. (7) 0.47 ± 0.10 18.8 ± 10.8 484 ± 107 127 ± 24 18.9 ± 2.8
Fisher et al. (13) 0.54 ± 0.08 11.9 ± 4.8 477 ± 137 99 ± 27 17.3 ± 4.5
Kong et al. (14) 0.56 ± 0.09 13.1 ± 8.4 502 ± 113 138 ± 49 16.5 ± 0.8
a

n = 6 for each study. No significant differences as compared by ANOVA.