. Author manuscript; available in PMC: 2014 Oct 23.

Published in final edited form as: Clin Pharmacol Ther. 1992 Jun;51(6):677–688. doi: 10.1038/clpt.1992.80

Table III.

Pharmacodynamic parameters for cortisol

Fitted jointly
Rm (ng/ml)	54.61 ± 15.36
Rb (ng/ml)	39.51 ± 0.85
tz (hr)	4.10 ± 1.15

	Treatment phase

	8 am	4 pm	p Value

Fitted separately
k_c (hr⁻¹)	0.35 ± 0.09	0.29 ± 0.06	NS
IC₅₀ (ng/ml)	1.19 ± 1.23	1.02 ± 1.0	NS
C_o (ng/ml)	152 ± 39	80 ± 30	<0.05
Suppression ratio	0.53 ± 0.11	0.64 ± 0.20	NS

Data are mean values ± SD; n = 6 subjects.

Rm, Mean of the cortisol concentrations; Rb, amplitude of the cortisol concentrations; tz, acrophase of the cortisol concentrations; k_c, first-order rate constant; C_o, cortisol concentration at time zero.