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Pharmacodynamic parameters for helper T cells
| Fitted jointly | ||||
| Rm (cells/mm3) | 647 ± 224 | |||
| Rb (cells/mm3) | 138 ± 71 | |||
| tz (hr) | 16.6 ± 3.9 | |||
| Treatment phase | ||||
| 8 am | 4 pm | Baseline | p Value | |
| Fitted separately | ||||
| kt (hr−1) | 0.55 ± 0.07 | 0.56 ± 0.24 | 0.82 ± 0.30 | NS |
| IC50 (ng/ml) | 7.22 ± 3.73 | 8.12 ± 4.34 | — | NS |
| Supperssion ratio | 0.72 ± 0.18 | 0.78 ± 0.21 | — | — |
Data are mean values ± SD; n = 6 subjects.
kt, First-order rate constant of helper T cell efflux from blood.
