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. 2014 Oct 3;2:144. doi: 10.1186/s40478-014-0144-4

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© Kreft et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Kif21b expression correlates with both AD and MS pathology. A) Kif21b expression was stratified for AD patients according to the Braak criteria. AD patients with more severe AD pathology (Braak stage 6) had significantly higher kif21b expression levels. B) For MS patients, the total area of grey matter demyelination was quantified and percentage of cortical demyelination was calculated. With increasing percentage of GM demyelination, enhanced kif21b expression was observed.