Table 3.
Presence of selected DAAs among SEARCH participants with physician-diagnosed T1D from the 2002, 2005, and 2008 incident cohorts who completed a SEARCH baseline study visit and had DAAs measured: the SEARCH for Diabetes in Youth Study
| Incidence Year |
|||||
|---|---|---|---|---|---|
| 2002 | 2005 | 2008 | P value* | P value for trend† | |
| n | 316 | 324 | 469 | — | — |
| Age at visit (years) | 11.1 (4.0) | 11.1 (4.0) | 10.5 (44) | 0.05 | 0.02 |
| T1D duration (months) | 13.0 (7.0) | 7.8 (5.2) | 8.2 (5.5) | <0.0001 | <0.0001 |
| DAA+ status | |||||
| GAD65+ | 186 (58.9) | 184 (56.8) | 288 (61.4) | 0.42 | 0.53 |
| IA-2A+ | 224 (70.9) | 230 (71.0) | 351 (74.8) | 0.36 | 0.25 |
| Either DAA+ | 267 (84.5) | 278 (85.8) | 413 (88.1) | 0.34 | 0.16 |
| DAA+ by age category (years)‡ | |||||
| 0–4 years | 20/22 (90.9) | 21/28 (75.0) | 52/61 (85.2) | 0.29 | 0.62 |
| 5–9 years | 89/102 (87.3) | 85/98 (86.7) | 134/152 (88.2) | 0.94 | 0.85 |
| 10–14 years | 108/131 (82.4) | 122/141 (86.5) | 152/174 (87.4) | 0.45 | 0.21 |
| ≥15 years | 50/61 (82.0) | 50/57 (87.7) | 75/82 (91.5) | 0.24 | 0.09 |
| DAA+ by sex‡ | |||||
| Female | 121/139 (87.1) | 128/145 (88.3) | 183/204 (89.7) | 0.75 | 0.46 |
| Male | 146/177 (82.5) | 150/179 (83.8) | 230/265 (86.8) | 0.43 | 0.23 |
Data are mean (SD) or n (%) unless otherwise indicated. IA-2A, IA-2 antibodies.
*P values for continuous variables were fit by using a general linear model with time period treated as a class variable. P values for categorical variables are based on χ2 test.
†P values for continuous variables were fit using a general linear model with time period treated as a continuous variable. P values for categorical variables were tested using the Cochran-Armitage test for trend.
‡Data are number positive/total tested (%).