Table 4.

Analysis of Clostridium difficile Infection Disease Outcomes Versus Serum Mannose-Binding Lectin Concentration Based on Deficiency Cutoffs of 50 and 100 ng/mL

Concentration	Cases (n = 308)	Controls (n = 145)	P Value	OR (95% CI)
<50 ng/mL	41 (13%)	18 (12%)	.79a	1.09 (.58–2.06)
<100 ng/mL	70 (23%)	23 (16%)	.09b	1.61 (.93–2.79)
	Death (n = 26)	Survival (n = 276)
<50 ng/mL	3 (12%)	37 (13%)	.78c	1.22 (.31–4.82)
<100 ng/mL	5 (19%)	64 (23%)	.84c	0.88 (.27–2.89)
	≥10 d (n = 174)	<10 d (n = 113)
<50 ng/mL	27 (16%)	10 (9%)	.10d	1.89 (.88–4.08)
<100 ng/mL	42 (24%)	22 (20%)	.35d	1.32 (.74–2.35)
	Recurrence (n = 81)	Nonrecurrence (n = 136)
<50 ng/mL	18 (22%)	13 (10%)	<.01e	3.18 (1.40–7.24)
<100 ng/mL	29 (36%)	24 (18%)	<.01e	2.61 (1.35–5.04)
	Severe (n = 125)	Nonsevere (n = 180)
<50 ng/mL	16 (13%)	25 (14%)	.78d	0.91 (.46–1.79)
<100 ng/mL	29 (23%)	41 (23%)	.93d	1.02 (.60–1.76)

Data regarding duration of symptoms and disease recurrence was unavailable for 18 and 60 of our cases, respectively. For disease recurrence, an additional 28 patients had died within the follow-up period prior to experiencing any recurrent symptoms and therefore could not be included in the analysis. Serum mannose binding lectin level was unavailable for an additional 3 individuals who were therefore excluded from analysis across all outcomes.

P values and ORs were calculated using univariate logistic regression and adjusted for the presence of significant covariates.

Abbreviations: CI, confidence interval; OR, odds ratio.

^a Age, body mass index (BMI), time delay between testing positive and recruitment, and the presence of diabetes.

^b Age, BMI, time delay between testing positive and recruitment, and the presence of diabetes and immunosuppressive therapy.

^c Age, BMI, score on Charlson comorbidity index, and disease severity at baseline.

^d No covariates were found to be significant and therefore P value remains unadjusted.

^e Age.