. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Nat Nanotechnol. 2014 May 11;9(8):648–655. doi: 10.1038/nnano.2014.84

Table 2.

Intravenous dose required to reduce target gene mRNA expression by 50% in vivo (mg/kg), termed the ED₅₀.

Gene	Lung	Heart	Kidney
VEcad	0.02	0.04	0.08
ICAM2	0.02	0.08	0.15
Tie2	0.04	0.12	0.12
VEGFR-2^*	0.05	0.10	0.25
Tiel^*	0.05	0.10	0.15

ED₅₀ value calculated from multigene silencing experiment (Fig. 2d).