Table 2. EC50 Values for Selenorhodamines 15b–18b with Colo-26 cCells and 0.5 or 1.0 J cm–2 of Light (λmax ± 2 nm), Dark Toxicities (LD50), and Ratios of LD50/EC50 with 1.0 J cm–2 of Light.
| EC50,a ×10–7 M (λmax ± 2 nm)c |
||||
|---|---|---|---|---|
| compd | 0.5 J cm–2 | 1.0 J cm–2 | LD50,b ×10–6 M (dark) | LD50/EC50 (laser, 1.0 J cm–2) |
| 15b | 3.1 ± 0.1 (613 nm) | 3.0 ± 0.1 (613 nm) | 7.8 ± 0.4 | 26 ± 2 |
| 16b | 2.0 ± 0.1 (611 nm) | 1.7 ± 0.1 (611 nm) | 9.5 ± 0.1 | 56 ± 4 |
| 17b | >5 (613 nm) | 4.1 ± 0.1 (613 nm) | 9.0 ± 0.1 | 22 ± 1 |
| 18b | 2.2 ± 0.1 (611 nm) | 1.4 ± 0.2 (611 nm) | 8.5 ± 0.2 | 61 ± 10 |
a
Mean of six determinations. Error limits are ±SD.
b
Mean of four determinations. Error limits are ±SD.
c
Values in parentheses are wavelengths of irradiation ± 2 nm.