Scheme 1. (A) Carbohydrate-Based Sulfamate Target Compounds with a Variable Linker Region 4a–4g and 5a–5g; (B) Synthetic Approach Towards Target Carbohydrate:Sulfamate Compounds Showing Variable Linker Region as ‘X’.

Reagents and conditions. (i) (a) 2.5 equiv BrCH(CO₂Et)₂, MeOH, rt, 20 min, (b) 3.0 equiv amino alcohol a–g, rt, 1 h; (ii) 6.0 equiv mCPBA, CH₂Cl₂, rt, 1–5 h; (iii) ClSO₂NCO, HCO₂H, DMA 0 °C → rt, 3 h; (iv) NaOH, MeOH, 0 °C to rt, 2–4 h; then Amberlite IR120-H⁺.