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. 2014 Sep 19;57(20):8398–8420. doi: 10.1021/jm500853v

Scheme 9. Synthesis of 2-Substituted Aromatic Chalcones and Flavanones.

Scheme 9

Reagents and conditions: (i) 60% KOH aq, MeOH, rt, 60 h; (ii) concentrated HCl, rt, overnight; (iii) microwave, HCl, EtOH, 150 °C, 1.5 h.

Without 2′-OH function for 8f.