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. 2014 Sep 19;57(20):8471–8476. doi: 10.1021/jm500964c

Figure 1.

Figure 1

(A) C-14 radiolabeled Py-Im polyamide 1, targeted to the DNA sequence 5′-WGWWCW-3′. (B) Compound levels of 1 in LNCaP and A549 tumor xenografts, compared against major host organs (kidney, liver, lung). Statistical comparison performed against the LNCaP tumor concentration of 1. (C) Calibration of the dual xenograft experiment against the respective single-tumor versions. All injections were performed intraperitoneally at 20 nmol per animal (NSG male mouse, N = 10) and tissues harvested 24 h following administration. Each data point represents an individual organ/tumor analyzed.