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. 2014 Oct 1;57(20):8307–8318. doi: 10.1021/jm500660f

Table 1. Structures and Ki Values of 5- or 6-Substituted Compounds against IDH1(R132H).

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  R5 R6 Ki (μM)
5 -Ph -H ∼50
4 -Bn -H 8.2
10 -(CH2)2Ph -H >50
11 -(CH2)3Ph -H >50
6 -OPh -H 46
12 -CONHOH -H >50
13 -CONHBn -H >50
14 -NHCOBn -H >50
15 -H -Ph >50
7 -H -Bn 5.9
16 -H –CH(CH3)Ph >50
17 -H -(CH2)2Ph 10
18 -H -(CH2)2(4-CO2Me-Ph) 27
8 -H -CONHOH 4.5