Scheme 7. Synthetic Route to Analogues 2e, 2f, and 6.

Reagents and conditions: 3-bromopropanol, Et₃N, acetonitrile, reflux, 3 h, 65%; (b) for 2e and 2f, TsCl, Et₃N, CH₂Cl₂, rt, 20 h, 33%; (c) for 2e, 4-tert-butylaniline, for 2f, 4-tert-butylphenol, Et₃N, acetonitrile, reflux, 18 h, 15–45%; (d) for 6, 4-phenylphenol, triphenylphosphine, DIAD, THF, rt, 18 h, 77%.