Table 4. DNA Gyrase and Topoisomerase IV IC50 Measurements.
| compd | DNA Ggyrase IC50 (μM) | topoisomerase IV IC50 (μM) | compd | DNA gyrase IC50 (μM) | topoisomerase IV IC50 (μM) |
|---|---|---|---|---|---|
| ciprofloxacin | 110 | 4 | 2h | 127 | 100 |
| 1a (terfenadine) | 190 | 206 | 2i | 410 | 110 |
| 1b | 127 | 273 | 9a | 93 | 110 |
| 1c | >500 | >333 | 9k | 90 | 133 |
| 1d | >500 | >333 | 9l | 73 | 247 |
| 1e | >500 | >333 | 9m | 93 | >333 |
| 1f | 133 | >333 | 3a | 93 | >333 |
| 1g | >500 | >333 | 3c | >333 | >333 |
| 1h | >500 | >333 | 3d | 260 | 267 |
| 1i | 440 | >333 | 3e | 247 | 260 |
| 1j | 100 | 133 | 3f | 17 | >333 |
| 1k | 133 | 333 | 3g | >333 | >333 |
| 1l | 73 | 100 | 3h | >333 | >333 |
| 1m | >500 | >333 | 3i | 263 | >333 |
| 1n | 13 | 100 | 3j | 93 | >333 |
| 1o | >500 | >333 | 3k | >333 | >333 |
| 1p | >500 | >333 | 3l | 80 | 133 |
| 2a | 93 | 320 | 3m | 93 | 227 |
| 2b | 93 | 100 | 3n | 250 | 280 |
| 2c | 93 | 147 | 3o | >333 | >333 |
| 2d | 90 | 213 | 4g | 125 | 160 |
| 2e | 193 | 250 | 5a | >333 | >333 |
| 2f | 100 | >333 | 5b | >333 | >333 |
| 2g | >500 | >333 | 6 | 50 | 160 |