Figure 4.

The anticancer efficacy of ASP-A in vivo following ASP-A multiple doses of treatments.

Notes: (A) Anticancer effect of ASP-A on H22-bearing mice. Quantification results were expressed as cancer weight (B) or body weight (C). Each point is the mean weight of eight tumors or mice; error bars are ± SD (n=8). Changes in the relative tumor volume (D) or body weight (E) of BEL-7402 xenografts following intraperitoneal injection of vehicle, ASP-A (7 mg/kg, 14 mg/kg, 28 mg/kg), and ADM (2 mg/kg) every day. The cancer size and body weight were monitored for 3 weeks. Results shown are mean ± SD (n=6).

Abbreviations: ADM, adriamycin; ASP-A, aspergiolide A; SD, standard deviation.