Table 1.

Pharmacokinetic parameters after intraperitoneal administration of ASP-A in mice at doses of 15 mg/kg and 30 mg/kg (n=5, mean ± SD)

Pharmacokinetic parameter	Unit	15 mg/kg	30 mg/kg
Kaa	1/minute	1.902	0.015
Keb	1/minute	0.016	0.053
Lag timec	minute	2.83	2.87
V/F(C)d	(mg/kg)/(μg/mL)	0.328	0.41
t1/2(Ka)e	minute	11.69	12.99
t1/2(Ke)f	minute	42.70	47.61
AUCg	(μg/mL)*minute	1,359.41	2,493.94
CL/F(s)h	mg/kg/minute/(μg/mL)	0.011	0.012
Tmaxi	minute	15.33	15.88
Cmaxj	μg/mL	20.96	39.50

Notes:

^aAbsorption rate constant;

^belimination rate constant;

^chysteresis parameter;

^drelative apparent volume of distribution;

^eabsorption half-life;

^felimination half-life;

^garea under the plasma concentration-time curve;

^hbody clearance;

ⁱtime needed to reach maximum plasma concentration;

^jmaximum plasma concentration.

Abbreviation: ASP-A, aspergiolide A; SD, standard deviation.