. 2014 Oct 17;9:4819–4828. doi: 10.2147/IJN.S67871

Table 2.

Pharmacokinetic parameters of BAY 55-9837 and BAY-CS-SeNPs in mouse plasma

Parameters	BAY 55-9837, mean ± SD	BAY-CS-SeNPs, mean ± SD
Dose (μg/mL)	625	625
Total dose (μg)	125	125
t_½ (hours)	0.32±0.06	20.81±0.75^**
AUC_0–t (μg·h/mL)	2.68±0.16	70.60±4.54^**
Cl_obs (mL/h)	43.97±3.76	1.56±0.13^**

Note:

^**

P<0.01 compared with BAY 55-9837.

Abbreviations: BAY-CS-SeNPs, BAY 55-9837-loaded selenium nanoparticles; SD, standard deviation; t_½, half-life; AUC_0–t, area under the curve from time 0 to last sampling point; Cl_obs, observed clearance.