Table 1.
Development of laboratory and clinical parameters in response to different immunosupressive agents.
| Parameter | Treatment | ||
|---|---|---|---|
| MTX + prednisolone (baseline) |
Cyclophophamide + prednisolone (week 18) |
Rituximab + MTX + prednisolone (week 59) |
|
| 6MWT (% of debit) | 380 m (63.60%) | 436 m (79.39%) | 536 m (90.44%) |
| FVC (% of debit) | 2.49 L (56.8%) | 3.36 L (76%) | 3.49 L (87%) |
| BGA | |||
| pO2 | 53 mmHg | 62 mmHg | 63 mmHg |
| pCO2 | 35 mmHg | 38 mmHg | 36 mmHg |
| DAS 28 | 7.47 | 7.7 | 2.8 |
| CRP | 131 mg/L | 72 mg/L | 1.7 mg/L |
| Ultrasound synovitis Score (PIP II–V) |
10 | 7 | 4 |