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. 2014 Oct 23;10(10):e1004685. doi: 10.1371/journal.pgen.1004685

Figure 6. Inorganic pyrophosphatase is targeted to peroxisomes in different species by various mechanisms.

Figure 6

(A) 3′ sequence of the C. elegans pyp-1 gene encoding inorganic pyrophosphatase (Gene ID: 177856) and its translation. The readthrough element and the PTS1 are highlighted. The reaction catalyzed by inorganic pyrophosphatase is shown. (B) Schematic drawings illustrating different mechanisms leading to peroxisomal isoforms of inorganic pyrophosphatase in a variety of species. Asterisks mark the positions of stop codons. M represents an alternative methionine start codon. (C) The readthrough derived PTS1 motif of human PPA2 was fused to GFP and analyzed for peroxisomal localization in HeLa cells. Scale bar represents 10 µm.