Table 5. Predicted pathogenicity of germline and somatic variants in MAP3K6 observed in a Maritime Canadian family and probands from a screen of 115 FGC cases negative for CDH1 mutations.
| Amino Acid Change | PolyPhen2 | PMut | PROVEAN | SIFT | EvoD | FATHMM* | MutationTaster |
| D200Y | Probably Damaging | Neutral | Deleterious | Damaging | Neutral | Tolerated/Passenger | Disease Causing |
| V207G | Benign | Neutral | Neutral | Tolerated | Deleterious | Tolerated/Passenger | Polymorphism |
| H506Ya | Possibly Damaging | Neutral | Neutral | Damaging | Deleterious | Tolerated/Passenger | Polymorphism |
| P946L | Probably Damaging | Pathological | Neutral | Tolerated | Neutral | Tolerated/Passenger | Disease Causing |
| P958T | Possibly Damaging | Neutral | Neutral | Neutral | Neutral | Tolerated/Passenger | N/A |
| p.F849Sfs*142 | - | - | - | - | - | - | - |
* FATHMM predictions for Missense Variants and Cancer-Associated Variants tools are both given.
a
The H506Y mutation is a somatic second-hit observed in FFPE tumor tissue from patient 1884.