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. 2014 Oct 23;10(10):e1004714. doi: 10.1371/journal.pgen.1004714

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© 2014 Carraro et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Expression of the master activator complex AcaCD from the promoter of acr1 (P_acr1) is directly repressed by Acr1 and Acr2 (red arrows). AcaCD directly activates the expression of the transfer genes of pVCR94, as well as the expression of the bet/exo homologous recombination system and numerous genes of unknown function (green arrows). AcaCD triggered the excision of SGI1 and MGIVmi1 by directly activating the expression of the RDF genes xis. AcaCD activates the expression of the vcrx001-like mobilization gene and other genes of unknown function in MGIVmi1. AcaCD also activates the expression of three genes coding for putative component of type IV secretion system (T4SS), as well as genes of unknown function such as S004, rep and S018 in SGI1. IncA/C plasmids likely provide additional functions for genomic islands dissemination such as oriT recognition and processing or formation of the mating pore (black hatched arrows). Genes are color-coded as in Figure 1A.