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. Author manuscript; available in PMC: 2014 Oct 23.
Published in final edited form as: Ther Deliv. 2013 Jun;4(6):741–757. doi: 10.4155/tde.13.44

Figure 6. Penetratin-improved in vivo gene delivery.

Figure 6

(A) Ad-VEGF (left ear) and Ad-β-gal (right ear) were injected intradermally into the ears of a mouse in the absence (i) and presence (ii) of penetratin for 4 days and vascular leakage was observed. The results show that delivery of the VEGF gene and resulting angiogenesis are greater in mice dosed with CPP/adenovirus than in mice dosed with adenovirus alone. (B) Ischematic lower limbs of mice injected with Ad-VEGF (i) or Ad-VEGF with penetratin (ii) showed intramuscular injection of Ad-VEGF in the presence of penetratin increased angiogenesis.

Adapted with permission from [43].