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. Author manuscript; available in PMC: 2014 Oct 23.

Published in final edited form as: ACS Nano. 2011 Mar 4;5(3):1693–1702. doi: 10.1021/nn102159g

The production of cytokines in cocultures where DCs were pretreated with LABL-NPs, cIBR-NPs, untargeted NPs, LABL peptide or cIBR peptide. (A) All nanoparticles increased the secretion of TNF-α compared to untreated DCs. (B) LABL-NPs, cIBR-NPs, LABL and cIBR peptides decreased the amount of IL-6 detected in the coculture of DCs and T cells relative to untreated DCs. Untargeted NPs increased the level of IL-6 production in the coculture of DCs and T cells (C) Untargeted NPs induced the production of IL-17 from activated OT-II T cells. LABL-NPs, cIBR-NPs, LABL and cIBR peptides did not stimulate the production of IL-17. *** indicates p<0.001 and ** indicates p<0.01.

The production of cytokines in cocultures where DCs were pretreated with LABL-NPs, cIBR-NPs, untargeted NPs, LABL peptide or cIBR peptide. (A) All nanoparticles increased the secretion of TNF-α compared to untreated DCs. (B) LABL-NPs, cIBR-NPs, LABL and cIBR peptides decreased the amount of IL-6 detected in the coculture of DCs and T cells relative to untreated DCs. Untargeted NPs increased the level of IL-6 production in the coculture of DCs and T cells (C) Untargeted NPs induced the production of IL-17 from activated OT-II T cells. LABL-NPs, cIBR-NPs, LABL and cIBR peptides did not stimulate the production of IL-17. *** indicates p<0.001 and ** indicates p<0.01.