Figure 7. Exposure to CdCl₂ suppressed the MMS-induced increase in MtDNA mutant frequency.

Median frequency (±95% CI) of erythromycin-resistant mutants per 10⁸ rho⁺ cells of heterozygous diploid strains containing both a wild type MIP1 allele and a mip1 allele encoding the Q264H variant in the presence or absence of methyl methanesulfonate (0 or 3 mM) or CdCl₂ (0, 2, 3, or 4 µM). Mutant frequencies were determined from at least 20 different independent cultures. CI, confidence interval; MMS, methyl methanesulfonate, mtDNA, mitochondrial DNA.