Table 2. Common and uniquely differentially expressed genes in tissues from WNV infected SW mice.
| Distribution | Tissues | Number of Genes | Gene Function | |||||
| Chemokine Ligands & Receptors | Cytokine Lignads & Receptors | Complement | Signal Transduction | Toll-like Receptors and Associated Proteins | Transcriptional Regulators | |||
| Common in 4 tissues | Spleen/Lung/Liver/Brain | 2 | Cxcl10 | Il12b | ||||
| Common in 3 tissues | Spleen/Lung/Liver | 14 | Ccl2 Ccl4 Ccl7 Ccl24 Cxcl9 | Il1rap Il10 | Myd88 Rapgef2 Daxx | Tollip Tlr3 | Maff Stat1 | |
| Spleen/Lung/Kidney | 1 | Il1rn | ||||||
| Spleen/Liver/Brain | 1 | Nox1 | ||||||
| Spleen/Kidney/Brain | 1 | Tnf | ||||||
| Lung/Liver/Brain | 1 | Cxcl2 | ||||||
| Lung/Liver/Brain | 1 | C7 | ||||||
| Common in 2 tissues | Spleen/Lung | 13 | Ccl5 Ccl19 | Il15 Il18 Il18rap Ifnb1 | Gusb Tubb5 | Tlr7 Ly96 | Ddit3 Hdac4 Max | |
| Spleen/Liver | 3 | C3ar1 | Il23r | Mapkapk5 | ||||
| Spleen/Kidney | 1 | Cxcl3 | ||||||
| Lung/Liver | 25 | Il1a Il6ra Ifng | C1qa C1qb C1r C2 C4a C6 Cfb | Fasl Fos Gapdh Hspb2 Map3k9 Map2k4 Pgk1 Plcb1 Ptk2 Shc1 | Tlr2 Tlr5 | Cebpb Creb1 Keap1 | ||
| Lung/Kidney | 5 | Ccl22 | Il13 Il22 Il23a | Hc | ||||
| Lung/Brain | 2 | Tnfsf14 | Mef2c | |||||
| Liver/Kidney | 3 | Il3 | C8b Mbl2 | |||||
| Liver/Brain | 1 | Kng1 | ||||||
| Tissue-Specific | Spleen | 5 | Ccl3 Cxcl5 | Pik3c2g | Atf2 Myc | |||
| Lung | 48 | Ccl11 Ccl17 Ccl21b Ccr1 Ccr2 Csf1 Csf3 Cxcr4 | Il1b Il10rb Il5 Il8rb | Cd40 Cdc42 Cltc Fxyd2 Gnas Gnaq Gnb1 Grb2 Hprt1 Hspb1 Itgb2 Limk1 Map2k1 Map2k6 Mapk3 Map3k7 Mknk1 Nfkb1 Pdgfa Pla2g4a Rac1 Raf1 Rhoa Rps6ka5 Rock2 Tgfb2 Tgfb3 Tgfbr1 | Tlr4 Tlr6 | Hmgn Jun Mef2a Nfatc3 Nfe2l2 Nr3c1 | ||
| Liver | 10 | Cxcl1 | Il1r1 Il22ra2 Il6 Il7 | C3 C8a Masp1 | Hras1 Mapk8 | |||
| Kidney | 7 | Il4 Ifna1 Lta | C9 Cfd Crp | Mef2b | ||||
| Brain | 1 | Il12a | ||||||
Commonly and uniquely expressed genes that were differentially expressed in spleen, lung liver, kidney and brain. All changes were found to be statistically significant, p<0.05.