Table 3. KEGG pathway enrichment from tissue-specific, differentially expressed genes.
| Spleen | |||||
| Term | Genes | Count | % | p Value | Benjamini |
| Cytokine-cytokine receptor interaction | CCL3, IL18RAP, TNF, CCL2, IL23R, CXCL5, IL18, CXCL9, CCL19, IL15, CCL5, CCL4, IL10, CCL7, CXCL10, CCL24, IFNB1, IL1RAP, IL12B | 19 | 46.3 | 4.90E-16 | 2.31E-14 |
| Toll-like receptor signaling pathway | CCL3, TNF, TOLLIP, LY96, CXCL9, TLR3, CCL5, STAT1, TLR7, CCL4, CXCL10, MYD88, IFNB1, IL12B | 14 | 34.1 | 8.93E-15 | 2.31E-13 |
| Chemokine signaling pathway | CCL24, CCL3, CCL2, CXCL5, CXCL9, CCL19, CCL5, STAT1, CCL4, CCL7, CXCL10 | 11 | 26.8 | 1.00E-07 | 1.73E-06 |
| Jak-STAT signaling pathway | IL23R, IFNB1, IL12B, IL15, STAT1, MYC, IL10 | 7 | 17.1 | 3.16E-04 | 4.10E-03 |
| Cytosolic DNA-sensing pathway | IFNB1, IL18, CCL5, CCL4, CXCL10 | 5 | 12.2 | 3.54E-04 | 3.68E-03 |
| NOD-like receptor signaling pathway | TNF, CCL2, IL18, CCL5, CCL7 | 5 | 12.2 | 5.62E-04 | 4.86E-03 |
| MAPK signaling pathway | MAX, TNF, MAPKAPK5, RAPGEF2, DAXX, MYC, DDIT3, ATF2 | 8 | 19.5 | 1.09E-03 | 8.07E-03 |
| *RIG-I-like receptor signaling pathway | TNF, IFNB1, IL12B, CXCL10 | 4 | 9.8 | 8.60E-03 | 5.46E-02 |
KEGG pathway enrichment from tissue specific DEGs: FDR<0.05.
* Indicates Biological pathway greater than the set FDR but is included, as this pathway has been implicated in WNV infections.