Figure 1. Specific IgG1 ELISA levels were high in active and relapsed VL but negative or substantially decreased in cured VL using unpaired serum samples.

[A] Indian VL pilot study (Trial 1). [B] Indian VL expanded study (Trial 2). [C] Sudanese VL. Mean and 95% CI are shown for each data set (solid black lines); note the different Y axis scales. In each study set, the means plus three standard deviations obtained using DAT-seronegative endemic healthy control (EHC) samples was used to calculate the cut-off value (dotted line) and p values of<0.05 were considered significant.