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. 2014 Oct 23;9(10):e110802. doi: 10.1371/journal.pone.0110802

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© 2014 Poddighe et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A): Lifespan, expressed as % survival rates, of wild type (WT) and PINK1^B9 flies. (B) and (C): Lifespan of PINK1^B9 treated with Mucuna pruriens extract (Mpe) 0.1%,only when adults (L⁻/A⁺) (panel B) or from their larval stage to the end of their life-cycle (L⁺/A⁺) (panel C), respectively, as compared to lifespan of untreated PINK1^B9 flies. (D): Lifespan of PINK1^B9 flies treated with L-Dopa (L⁺/A⁺) 0.01%. *indicates p<0.05 at Kaplan-Meier survival curves (Gehan-Breslow–Wilcoxon - GraphPad Prism 5.01) between WT and untreated PINK1^B9 (A) and between untreated PINK1^B9 and PINK1^B9 fed Mpe 0.1% (C).