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(A) In DEB PKS-AT5, Q643 has been proposed to orient the incoming (2S)-methylmalonyl-CoA so that Y742 makes a hydrophobic interaction with the methyl-group and H745 sterically hinders the entry of (2R)-methylmalonyl-CoA [26]. (B) In ZmaA-AT, F193 is not positioned to orient the incoming substrate, which may allow hydroxymalonyl-ACP with (2R)-stereochemistry to enter the substrate pocket unhindered.
