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. 2014 Oct 23;9(10):e110969. doi: 10.1371/journal.pone.0110969

Figure 3. Unstable cellular senescent state is associated with loss of DDR foci.

Figure 3

a. Bar graphs show the average number of γH2AX foci ± s.e.m. per cell before (young and pre-sen) and at the indicated time points after senescence establishment in two different types of fibroblast cell strains, BJ and WI-38. b. Bar graphs show the fraction of γH2AX foci-positive cells ± s.e.m. at the indicated time points after senescence establishment in BJ vs WI-38. Cells were considered foci-positive if the number of foci were more than three (*** p-value <0.001). c. WI-38 senescent cells (WI-38 sen) in culture tend to reduce in number with time (day 30 and day 60) whereas BJ senescent cells (BJ sen) do not. The graph shows the fold change in cell number ± s.d. normalized to the number of senescent cells plated at day 0 (** p-value <0.01).