Table 8. Frequencies of specific toxicities and treatment switches among Ghanaian cohort on long-term cART.
| Toxicity | Frequency of toxicity among patients who developed any toxicity on ART n (%), n = 1,603 | Proportion of patients who developed toxicity n (%)§ n = 4,039 | Frequency of treatment switches due to specific toxicity# n (%) | Proportion of patients with treatment switch due to toxicity, (%) n = 4,039 |
| Anemia | 675 (42.1) | 527 (13.0) | 62 (11.8) | 1.5 |
| Skin rash | 295 (18.4) | 281 (7.0) | 44 (15.7) | 1.1 |
| Neuropsychiatric toxicity | 235 (14.7) | 218 (5.4) | 39 (17.9) | 1.1 |
| Peripheral neuropathy | 181 (11.3) | 181 (4.5) | 83 (45.9) | 2.1 |
| Severe hepatotoxicity | 143 (8.9) | 143 (3.5) | 8 (5.6) | 0.2 |
| Lipoatrophy | 40 (2.5) | 40 (1.0) | 34 (85.0) | 0.8 |
| Ptylism | 14 (0.9) | 14 (0.3) | 0 (0.0) | 0.0 |
| Gastrointestinal disorders | 12 (0.7) | 12 (0.3) | 0 (0.0) | 0.0 |
| Lactic acidosis | 4 (0.2) | 4 (0.1) | 0 (0.0) | 0.0 |
| Myalgia | 3 (0.2) | 3 (0.1) | 0 (0.0) | 0.0 |
| Hyperpigmentation | 3 (0.2) | 3 (0.1) | 0 (0.0) | 0.0 |
| Pancreatitis | 1 (0.1) | 1 (0.0) | 1 (100.0) | 0.0 |
| Column total | 1,603 | 1,427 (35.3) | 271 | 6.8 |
#
This refers to the number of patients switching treatment due to specific toxicity specified on the row. % was determined by dividing the number of patients switching treatment due to a specific toxicity by the total number of patients with that particular toxicity in question.
§
n(%) n refers to the number of patients who experienced specific toxicity and the % refers to number of patients with toxicity divided by the total number of patients starting ART which was 4,039. An individual patient may experience more than one toxicity during follow up and may experience a specific toxicity more than one episode during follow up.