Table II.
NMR lipoprotein particle concentrations and sizes.
| Lipoprotein Subclasses | Pediatric KD (n=192) | Pediatric HC (n=45) | P-value | Adult KD (n=63) | Adult HC (n=45) | P-value |
|---|---|---|---|---|---|---|
| Total VLDL/Chylomicron particles (VLDLC-P) (nmol/L) | 43.4 (39.9-46.9) | 51.6 (44.4-58.9) | 0.046 | 50.3 (43.2-57.4) | 72.1 (63.7-80.6) | <0.001 |
| Large VLDL/Chylomicron particles (VLC-P) (nmol/L) | 1.4 (0.9-2.0) | 3.1 (1.9-4.2) | 0.01 | 1.9 (1.4-2.5) | 2.1 (1.5-2.8) | 0.61 |
| Medium VLDL particles (VM-P) (nmol/L) | 18.3 (16.0-20.5) | 14.2 (9.5-18.9) | 0.12 | 16.5 (12.9-20.1) | 23.4 (19.2-27.7) | 0.017 |
| Small VLDL particles (VS-P) (nmol/L) | 23.7 (21.8-25.6) | 34.4 (30.4-38.4) | < 0.001 | 31.9 (26.9-36.8) | 46.5 (40.6-52.4) | < 0.001 |
| Total LDL particles (LDL-P) (nmol/L) | 935 (894-975) | 1098 (1014-1182) | 0.001 | 937 (854-1020) | 1056 (957-1155) | 0.075 |
| IDL particles (IDL-P) (nmol/L) | 14 (9-18) | 113 (104-123) | < 0.001 | 62 (50-75) | 89 (74-104) | 0.009 |
| Large LDL particles (LL-P) (nmol/L) | 382 (358-406) | 610 (560-661) | < 0.001 | 498 (453-544) | 533 (478-587) | 0.35 |
| Small LDL particles (total) (LS-P) (nmol/L) | 539 (494-584) | 374 (281-467) | 0.002 | 376 (293-458) | 434 (336-533) | 0.38 |
| Total HDL particles (HDL-P) (μmol/L) | 30.4 (29.8-30.9) | 30.5 (29.3-31.8) | 0.77 | 34.0 (32.5-35.4) | 40.5 (38.8-42.2) | < 0.001 |
| Large HDL particles (HL-P) (μmol/L) | 9.0 (8.5-9.4) | 4.9 (4.0-5.8) | < 0.001 | 6.8 (6.0-7.7) | 7.7 (6.7-8.7) | 0.21 |
| Medium HDL particles (HM-P) (μmol/L) | 3.2 (2.7-3.7) | 9.6 (8.5-10.7) | < 0.001 | 11.7 (10.1-13.3) | 12.4 (10.4-14.3) | 0.61 |
| Small HDL particles (HS-P) (μmol/L) | 18.2 (17.6-18.8) | 16.1 (14.8-17.3) | 0.003 | 15.4 (14.1-16.8) | 20.5 (18.9-22.1) | < 0.001 |
| VLDL particle size (VZ) (nm) | 53.5 (52.1-54.8)* | 44.2 (41.2-47.3)† | < 0.001 | 47.1 (45.9-48.3)‡ | 43.5 (42.1-44.9)§ | < 0.001 |
| LDL particle size (LZ) (nm) | 21.2 (21.1-21.3) | 21.1 (20.9-21.3) | 0.49 | 21.1 (21.0-21.2) | 20.9 (20.8-21.1) | 0.10 |
| HDL particle size (HZ) (nm) | 9.1 (9.0-9.2) | 9.2 (9.1-9.3) | 0.05 | 9.2 (9.1-9.3) | 9.2 (9.1-9.4) | 0.68 |
| Total Triglyceride (TG) (mg/dL) | 82 (75-89) | 105 (90-119) | 0.008 | 93 (84-103) | 116 (105-127) | 0.003 |
| Total VLDL/Chylomicron Triglyceride (NVCTG) (mg/dL) | 54 (47-61) | 69 (55-84) | 0.06 | 63 (54-72) | 81 (70-92) | 0.012 |
| Total HDL cholesterol (HDL-C) (mg/dL) | 50 (49-52) | 48 (45-51) | 0.13 | 54 (51-56) | 63 (60-66) | < 0.001 |
| Total LDL cholesterol (LDL-C) (mg/dL) | 85 (82-88) | 106 (100-113) | < 0.001 | 87 (81-94) | 95 (88-103) | 0.12 |
| Total Cholesterol (TC) (mg/dL) | 148 (145-152) | 169 (161-176) | < 0.001 | 154 (147-161) | 176 (168-185) | < 0.001 |
| Ratio of Total cholesterol/HDL cholesterol | 3.1 (2.9-3.2) | 3.6 (3.4-3.8) | <0.001 | 3.0 (2.8-3.2) | 2.9 (2.7-3.2) | 0.83 |
Values are model-estimated means (95% CI). P values are after Holm's correction for multiple testing. HC=healthy controls; VLDL=very-low-density lipoprotein; LDL=low-density lipoprotein; IDL=intermediate-density lipoprotein; HDL=high-density lipoprotein
*
n=191
†
n=39
‡
n=55
§
n=43