Table 3. Determinants of Low vs. high risk for PHLF.

Risk category	Imaging	Laboratory data	Patient factors	Number of safe segments for resection
Low	• Predicted FLR >25%	• Prothrombin activity ≥70%	• No history of cirrhosis	Up to 6 (80% of functional liver volume)
	• Normal splenic size, no vascular collaterals	• Hyaluronic acid <200 ng/mL	• No previous hepato-toxic chemotherapy
		• Platelets >300,000/µL
	• Indocyanine green plasma disappearance rate ≥17.6%/min	• Normal serum bilirubin level
High	• Predicted FLR ≤25%	• Prothrombin activity <70%	• History of cirrhosis	No more than 3 (60% of functional liver volume)
	• Splenomegaly, presence of vascular collaterals	• Hyaluronic acid ≥200 ng/mL	• Previous administration of hepato-toxic chemotherapy
		• Platelets <100,000/µL
	• Steatohepatitis	• Hyperbilirubinemia
	• Indocyanine green plasma disappearance rate <17.6%/min

PHLF, post-hepatectomy liver failure.