Table 3. Determinants of Low vs. high risk for PHLF.
Risk category | Imaging | Laboratory data | Patient factors | Number of safe segments for resection |
---|---|---|---|---|
Low | • Predicted FLR >25% | • Prothrombin activity ≥70% | • No history of cirrhosis | Up to 6 (80% of functional liver volume) |
• Normal splenic size, no vascular collaterals | • Hyaluronic acid <200 ng/mL | • No previous hepato-toxic chemotherapy | ||
• Platelets >300,000/µL | ||||
• Indocyanine green plasma disappearance rate ≥17.6%/min | • Normal serum bilirubin level | |||
High | • Predicted FLR ≤25% | • Prothrombin activity <70% | • History of cirrhosis | No more than 3 (60% of functional liver volume) |
• Splenomegaly, presence of vascular collaterals | • Hyaluronic acid ≥200 ng/mL | • Previous administration of hepato-toxic chemotherapy | ||
• Platelets <100,000/µL | ||||
• Steatohepatitis | • Hyperbilirubinemia | |||
• Indocyanine green plasma disappearance rate <17.6%/min |
PHLF, post-hepatectomy liver failure.